• Dr. Brownstein: $14,000 For New Cholesterol-Lowering Drugs? We Must Be Out Of Our Minds!

    The best metric for measuring the effectiveness of a drug is the NNT or the number of patients needed to be treated with the drug to prevent 1 clinically significant endpoint. In the case of statins and presumably in the case of the new class of drug to lower cholesterol the NNT for primary prevention is between 100-500!! I would not want to take an expensive dangerous drug that is likely to increase my incidence of diabetes (which in and of itself increased heart attacks), heart failure, dementia, muscle aches, fatigue, and oxidative stress as a result of lower vitamin D and coenzyme Q10. For what? To lower my chances of an MI or stroke by less than 1%? I would rather take up jogging and eat better. I would rather bet on black. The statin drugs have been a disaster as they don’t work in the majority of people who take them. Now, we want to spend over $14,000 per year in a new class of cholesterol-lowering drugs? We must be out of our minds.

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  • Dr. Brownstein: $14,000 For New Cholesterol-Lowering Drugs? We Must Be Out Of Our Minds!

    I would like to add that there is absolutely no proof anywhere that cholesterol causes any disease.